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A New Leash On Life

First-Ever Science-Backed Longevity Protocols for Your Furry Friends
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Pet longevity starts at the cellular level

At Petspan, we're dedicated to bringing cutting-edge longevity treatments to pets by addressing aging at its source—the cellular level. Petspan’s longevity protocol is designed not just to extend the years we have with our pets but to ensure those years are healthy and vibrant.

By targeting the root causes of aging, we can create more healthy years together with our pets, allowing us to make memories that last a lifetime.
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4 simple steps to start —
4 simple steps to start —
4 simple steps to start —
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Sign up and schedule your visit

Start your pet’s longevity journey by answering basic questions about their medical history.  This helps Petspan tailor a personalized longevity protocol to your pet's needs.

Next, pick a time and conveniently get longevity-focused care from a licensed Petspan vet from home.

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Virtual visit with a vet

During your consultation, the Petspan veterinarian will review your responses and ask specific questions to fully understand your pet's health.

They will guide you through a video examination and help develop a personalized longevity protocol, all from the comfort of your home with minimal stress.

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Medication conveniently delivered to your door

If your pet is a good candidate, your Petspan veterinarian will discuss a research-backed longevity plan and prescribe medication that will be shipped directly to you.

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Continuous care

We’ll follow up with you to check in on your pet’s clinical response and encourage you to get follow up diagnostics, such as blood tests, to chart improvements in your pet’s health indicators.

We partner with you throughout the journey to ensure your pet stays as healthy as possible for as long as possible.

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More time with the pets we love

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Expert Longevity Vets
Petspan vets specialize in the latest pet longevity treatments.
Easy to Access
Convenient, low-stress telemedicine visits for you and your pet.
Personalized Treatments
Tailored treatments to maximize your pet's healthy lifespan.

The Scienceof Rapamycin

As our animals age, the mTOR pathway becomes overactive, leading to uncontrolled cell growth and inflammation, accelerating aging, and causing age-related diseases.

By intermittently inhibiting mTOR with rapamycin, a medication known for its ability to target this critical pathway, we can help the body remove dysfunctional cells, called senescent cells, enhancing the healthy lifespan of our pets.
About the protocol
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Pioneering Studies on Pet Longevity

Delayed-release rapamycin halts progression of feline hypertrophic cardiomyopathy: RAPACAT trial results.​
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A placebo-controlled trial assessing the safety and cardiac effects of low-dose rapamycin in 17 healthy dogs.
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Weekly Rapamycin Study in Feline Cardiomyopathy: Pilot Trial
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Rapamycin Trial: Effects on Middle-Aged Dogs, Randomized Study
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Thrilled to begin the rapamycin protocol and explore its potential benefits!

Mamba

4 years

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I love Petspan, and the work they are doing to help me be healthier!

Rascal

4 years

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I’m all set to begin the rapamycin protocol—looking forward to positive changes!

Iverson

7 years

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Kicking off the rapamycin regimen, and I can’t wait to experience the results!

Jack Jack
5 years

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Eager to see how rapamycin can enhance my health and longevity!

Annabelle
15 years

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Begin your Petspan journey

Help your pet live longer and healthier with our personalized plans. Start with a virtual consultation today.
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Rapamycin for your Best Friends

Rapamycin is a medication that inhibits mTOR, a common and important cellular pathway in many different species including dogs, cats and even humans.
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In studying this medication, early researchers were surprised to find that animals receiving it had not only improved tissue function but also significantly longer life expectancy.
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Since those initial studies, further research has shown beneficial effects of rapamycin in many species for many different age-associated conditions.

As our bodies age, dysfunctional cells can overwhelm the body’s ability to remove them and accumulate, which contributes to age-related decline in function.
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While some damaged cells are marked for destruction, a process called apoptosis, others enter a different state called senescence.
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Senescent cells no longer perform regular cellular functions but they still secrete harmful pro-inflammatory molecules leading to a low-grade chronic inflammatory state.
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By using rapamycin to inhibit mTOR intermittently, we allow the body an opportunity to remove these “zombie cells” improving overall tissue health and function in many different organ systems.
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Rapamycin is currently being studied not just for improving overall longevity in dogs, but also as a treatment for many chronic diseases of aging that account for the top causes of death or euthanasia in our pet populations.
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Current studies are underway looking at rapamycin’s effects on conditions such as chronic kidney disease, cancer, dementia and heart disease in cats and dogs.

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Petspan uses the most up-to-date protocols and dosing from published research to create evidence-based treatment plans for our pet patients.
Your Questions Answered —
Your Questions Answered —
Your Questions Answered —
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Rapamycin
How does Petspan work?

While we are actively working to expand access to longevity treatments for all pets, we currently operate only in New York, California, Virginia, Idaho, Vermont, Pennsylvania, Florida, New Jersey and DC. We will be adding additional states soon. If you join our email list, we’ll send an announcement as soon as we add a new state.

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How does Petspan ensure the medication is high quality?

While we are actively working to expand access to longevity treatments for all pets, we currently operate only in New York, California, Virginia, Idaho, Vermont, Pennsylvania, Florida, New Jersey and DC. We will be adding additional states soon. If you join our email list, we’ll send an announcement as soon as we add a new state.

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

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What is included in my plan?

While we are actively working to expand access to longevity treatments for all pets, we currently operate only in New York, California, Virginia, Idaho, Vermont, Pennsylvania, Florida, New Jersey and DC. We will be adding additional states soon. If you join our email list, we’ll send an announcement as soon as we add a new state.

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

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Is this covered by pet insurance?

While we are actively working to expand access to longevity treatments for all pets, we currently operate only in New York, California, Virginia, Idaho, Vermont, Pennsylvania, Florida, New Jersey and DC. We will be adding additional states soon. If you join our email list, we’ll send an announcement as soon as we add a new state.

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

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Is Petspan available in all states?

While we are actively working to expand access to longevity treatments for all pets, we currently operate only in New York, California, Virginia, Idaho, Vermont, Pennsylvania, Florida, New Jersey and DC. We will be adding additional states soon. If you join our email list, we’ll send an announcement as soon as we add a new state.

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

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When will my pet’s prescription ship?

If approved after your consultation with your Petspan veterinarian, it takes two days for the pharmacy to process the medication and another two to three days for it to ship. Note that the pharmacy is closed on weekends, which can extend the processing and shipping times. When your order ships, you will receive a tracking link.

How do I provide specific delivery instructions?

If you need to provide the Post Office with specific delivery instructions, please go to their website (usps.com) and click Quick Tools -> Track a Package. There is a section called "How do I leave delivery instructions."

What payment methods do you accept?

We currently accept major credit cards such as Mastercard, Visa, and American Express.

When will my card be charged?

Once you sign up for your pet’s consultation, your card will be charged for the cost of the virtual visit. If during the visit your pet is determined to be a good candidate for rapamycin treatment, you will then be billed for the medication and it will be sent to the pharmacy to be filled and shipped. You will continue to be billed based on your subscription duration unless you make a change in your plan. Your prescription will be auto renewed based on your subscription duration.

How do I pause or cancel orders?

You can cancel or pause your subscription at anytime by logging into your pet’s patient portal and navigating to your Subscriptions. For any additional questions, please message us in the application or email us at support@mypetspan.com.

What is included in the Rapamycin Protocol?

The Rapamycin Protocol is a fully comprehensive and personalized treatment plan guided by your Petspan veterinarian and based on the most recently published studies in dogs and cats.

  • Medical review by a US-based, licensed veterinarian. Petspan veterinarians analyze your pet’s medical history and examination findings to prescribe personalized health recommendations. If your veterinarian deems the medication appropriate for your pet, you will be receive a recommended treatment plan for your pet, explaining the benefits and what to expect. You will need to meet with your Petspan veterinarian via a virtual video consultation every 6 months to continue the medication, but we recommend messaging your pet’s care team monthly to track progress and response - or sooner if you have any concerns.
  • Prescriptions delivered to your door. Our US-based pharmacies, which are LegitScript-certified, handle the direct shipment of your pet’s medication to your doorstep. We prioritize selecting medications with the highest bioavailability to maximize their effectiveness.
What testing is recommended for pets on Rapamycin therapy?

Regular diagnostic testing including basic blood and urine tests are recommended prior to starting treatment, at 3 months after initiating treatment, and every 6 months thereafter as long as your pet is on the medication. We recommend uploading these results to your pet’s patient portal for Petspan care team review. This allows your Petspan veterinarian to track improvements in your pet’s health indicators and monitor for any side effects. These tests can be done with your regular veterinarian or via a mobile veterinary service in your area.

How frequently do you take your Rapamycin dose on the longevity protocol?

Upon thorough medical review and screening, should your pet be deemed suitable for the Petspan Rapamycin Protocol, administration of Rapamycin will occur just once a week. For instance, should your pet’s current weekly dosage be 3 mg, and you're given 1 mg pills, you'll give all three pills on a single day, as opposed to distributing them over the week.

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The reason for this methodology stems from the cyclical nature of the benefits Rapamycin offers for anti-aging. Unlike transplant patients who take Rapamycin daily, the longevity benefits are drawn from the intermittent inhibition of mTOR. The therapeutic benefit of Rapamycin is derived from pulsated inhibition of mTOR, avoiding continuous inhibition. This approach prevents bloodstream concentrations of rapamycin that could inhibit mTOR-Complex 2, leading to immune suppression, which we aim to evade.

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By adhering to a weekly dosage, we sidestep the immunosuppressive side effects of Rapamycin. We strive to administer Rapamycin in a manner that leverages the mTOR inhibitory benefits, such as stimulating autophagy, in cycles, and then returning to baseline mTOR activity.

Why do some sources mention a risk of cancer associated with rapamycin?

The risk of cancer is related to daily dosing for transplant patients, whereas our approach involves intermittent dosing every 7 days to avoid immune suppression. This distinction has varying implications for cancer. Rapamycin inhibits mTOR, exhibiting anti-cancer properties by preventing cell proliferation and inflammatory conditions conducive to cancer. Daily dosing may suppress the immune system, while our low-dose cyclical dosing enhances immune function, potentially contributing to rapamycin's anti-cancer benefits. For more information about rapamycin, immune health, and cancer, please visit our Petspan blog to access dedicated articles.

What side effects are possible when taking rapamycin?

At the Petspan protocol dose and frequency, multiple species-specific studies have found no statistically significant adverse effects of the medication when compared with placebo.

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At higher doses and/or with chronic (i.e. daily) use, the following rare side effects have been reported:

  • Decreases in red and white blood cells (thrombocytopenia, anemia, leukopenia)
  • Increases in fats in the blood (hyperlipidemia)
  • Impaired wound healing
  • Kidney damage
  • Altered insulin sensitivity

Most of the effects noted have been mild and reversible with discontinuation of the medication. However, this is the reason your Petspan care team recommends baseline and recheck blood testing to address any changes early. If you note signs of possible skin infection - or if your pet becomes acutely ill - you should see your regular veterinarian promptly and advise them of all medications your pet takes, including rapamycin.